CAS No. 2497525-96-7
Chemical Structure
Check the
IAMA-6
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 3-(dimethylsulfamoyl)-4-(8,8,8-trifluorooctylamino)benzoic acid | |
|---|---|---|
| CAS Number | 2497525-96-7 | |
| Molecular Formula |
C17H25F3N2O4S |
|
| Molecular Weight (MW) | 410.45 | |
| InChIKey | ZAJDYPRGNPKHEI-UHFFFAOYSA-N |
Biological Activity
IAMA-6 is a potent, selective, and orally bioavailable inhibitor of the Na-K-2Cl cotransporter 1 (NKCC1). By targeting NKCC1, it regulates intracellular chloride homeostasis and restores physiological GABAergic inhibitory neurotransmission. This restoration modulates neuronal circuit excitability, resulting in enhanced synaptic plasticity and potential attenuation of cognitive impairment in neurodevelopmental conditions, including Down syndrome and autism. [1]
How to Prepare Stock Solution?
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Note: Technical data last updated: Sep 1, 2026.