CAS No. 2714434-21-4
Batch:
Purity:99.96
Chemical Structure
Check the
IAG933
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[(2S)-5-chloro-6-fluoro-2-phenyl-2-[(2S)-pyrrolidin-2-yl]-3H-1-benzofuran-4-yl]-5-fluoro-6-(2-hydroxyethoxy)-N-methylpyridine-3-carboxamide | |
|---|---|---|
| CAS Number | 2714434-21-4 | |
| Molecular Formula |
C27H26ClF2N3O4 |
|
| Molecular Weight (MW) | 529.96 | |
| InChIKey | HUVOYQMXUNTUAI-DCFHFQCYSA-N |
IAG933 is a small-molecule inhibitor targeting the YAP/TAZ-TEAD protein-protein interaction downstream of the Hippo signaling pathway. Disruption of this interaction across TEAD paralogs induces YAP eviction from chromatin, leading to suppressed Hippo-mediated transcriptional activity, induction of cell death, and inhibition of tumor growth and metastatic spread in Hippo-driven solid tumor models, including NCI-H2052 mesothelioma cells. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(188.69 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(188.69 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- IAG933 Mechanism of Action: TEAD Inhibition in Mesothelial Cell Research
- IAG933 Clinical Trials
- IAG933 Solubility in DMSO
- IAG933 Stock Solution
- IAG933 Storage
- IAG933 Stability
- IAG933 Molecular Weight
- IAG933 Chemical Structure (2D and 3D)
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- IAG933 SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.