CAS No. 1853164-83-6
Batch:
Purity:99.23
Chemical Structure
Check the
IACS-6274
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[(2R)-4-[6-[[2-[4-(3,3-difluorocyclobutyl)oxy-6-methyl-2-pyridinyl]acetyl]amino]pyridazin-3-yl]-2-fluorobutyl]-N-methyltriazole-4-carboxamide | |
|---|---|---|
| CAS Number | 1853164-83-6 | |
| Molecular Formula |
C24H27F3N8O3 |
|
| Molecular Weight (MW) | 532.52 | |
| InChIKey | GEHZIZWHNLQFAS-OAHLLOKOSA-N |
IACS-6274 (IPN60090) is a potent, selective, and orally active glutaminase inhibitor designed to block glutamine metabolism in cancer cells. By inhibiting glutaminase, it disrupts the conversion of glutamine to glutamate, suppressing tricarboxylic acid (TCA) cycle intermediate replenishment and attenuating downstream energy production and macromolecular biosynthesis. This metabolic blockade selectively suppresses tumor cell proliferation and survival while modulating the tumor immune microenvironment. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
5 mg/mL
(9.38 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.