CAS No. 2160546-07-4

Batch: Purity:99.99
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BBP- 398 (IACS-13909) Chemical Structure
Chemical Structure
Check the BBP- 398 (IACS-13909) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-[3-(2,3-dichlorophenyl)-2H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methylpiperidin-4-amine
CAS Number 2160546-07-4
Molecular Formula

C17H18Cl2N6
Molecular Weight (MW) 377.27
SMILES CC1(N)CCN(CC1)C2=CN=C3C(=N2)[NH]N=C3C4=CC=CC(=C4Cl)Cl
InChIKey AMADCPJVPLUGQO-UHFFFAOYSA-N

Ordering Information

Biological Activity

BBP-398 (IACS-13909) is a potent, allosteric inhibitor targeting Src homology 2 domain-containing phosphatase (SHP2). By binding to the allosteric site of SHP2, it locks the enzyme in an inactive conformation and suppresses downstream signaling through the MAPK pathway. This inhibition leads to reduced ERK phosphorylation and impairs cell proliferation and survival in receptor tyrosine kinase-driven cancer models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 75 mg/mL (198.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.