CAS No. 1300031-49-5

Batch: Purity:99.99
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I-BET151 (GSK1210151A) Chemical Structure
Chemical Structure
Check the I-BET151 (GSK1210151A) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 7-(3,5-dimethyl-1,2-oxazol-4-yl)-8-methoxy-1-[(1R)-1-pyridin-2-ylethyl]-3H-imidazo[4,5-c]quinolin-2-one
CAS Number 1300031-49-5
Molecular Formula

C23H21N5O3
Molecular Weight (MW) 415.44
SMILES CC1=C(C(=NO1)C)C2=C(C=C3C(=C2)N=CC4=C3N(C(=O)N4)C(C)C5=CC=CC=N5)OC
InChIKey VUVUVNZRUGEAHB-CYBMUJFWSA-N

Biological Activity

I-BET151 (GSK1210151A) is a selective inhibitor of the bromodomain and extra-terminal (BET) family proteins, targeting BRD2, BRD3, and BRD4. It disrupts BET protein binding to chromatin, downregulating key oncogenic genes such as MYC, BCL2, and CDK6. This mechanism induces cell cycle arrest and apoptosis in MLL-fusion leukemia cells, significantly reducing leukemic burden in vivo. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 83 mg/mL (199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 83 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Dawson MA, et al. Nature. 2011;478(7370):529-33.

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Note: Technical data last updated: Sep 1, 2026.