CAS No. 1260907-17-2

Batch: Purity:99.87
Check CoA
Molibresib (I-BET-762) Chemical Structure
Chemical Structure
Check the Molibresib (I-BET-762) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide
CAS Number 1260907-17-2
Molecular Formula

C22H22ClN5O2
Molecular Weight (MW) 423.9
SMILES CCNC(=O)CC1C2=NN=C(N2C3=C(C=C(C=C3)OC)C(=N1)C4=CC=C(C=C4)Cl)C
InChIKey AAAQFGUYHFJNHI-SFHVURJKSA-N

Biological Activity

Molibresib (I-BET-762) is a potent synthetic inhibitor targeting bromodomain and extra-terminal (BET) family proteins, including BRD2, BRD3, and BRD4. By displacing BET proteins from acetylated histones on chromatin, it disrupts transcriptional complexes and downstream gene expression. Consequently, Molibresib suppresses the production of proinflammatory proteins in activated macrophages and attenuates systemic acute inflammatory responses in vivo. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 84 mg/mL (198.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 42 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Free Aliquotting Service

Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.

Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.

Reference

[1] Nicodeme E, et al. Nature. 2010;468(7327):1119-23.

Jump to

Note: Technical data last updated: Sep 1, 2026.