CAS No. 118-42-3
Batch:
Purity:99.93
Chemical Structure
Check the
Hydroxychloroquine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol | |
|---|---|---|
| CAS Number | 118-42-3 | |
| Molecular Formula |
C18H26ClN3O |
|
| Molecular Weight (MW) | 335.87 | |
| InChIKey | XXSMGPRMXLTPCZ-UHFFFAOYSA-N |
Hydroxychloroquine is an antimalarial and immunomodulatory agent that inhibits autophagy and impairs lysosomal function. By interfering with antigen presentation and Toll-like receptor signaling, it suppresses the production of pro-inflammatory cytokines including TNF-α, IFN-γ, and IL-6 from peripheral blood mononuclear cells, while upregulating IL-10. Additionally, hydroxychloroquine demonstrates antithrombotic and antiplatelet activity, reduces endothelin-1 secretion, and restores angiogenesis in TNF-α-treated endothelial cells. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
67 mg/mL
(199.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 67 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.