CAS No. 2657-25-2

Batch: Purity:99.88
Check CoA
4'-Hydroxychalcone Chemical Structure
Chemical Structure
Check the 4'-Hydroxychalcone product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (E)-1-(4-hydroxyphenyl)-3-phenylprop-2-en-1-one
CAS Number 2657-25-2
Molecular Formula

C15H12O2
Molecular Weight (MW) 224.25
SMILES C1=CC=C(C=C1)C=CC(=O)C2=CC=C(C=C2)O
InChIKey UAHGNXFYLAJDIN-IZZDOVSWSA-N

Ordering Information

Biological Activity

4'-Hydroxychalcone is a natural retrochalcone that acts as an inhibitor of TNFα-induced NF-κB pathway activation and an activator of BMP signaling. By suppressing the NF-κB signaling cascade and modulating BMP-mediated pathways, 4'-hydroxychalcone regulates downstream inflammatory responses and cellular differentiation phenotypes. These biological activities demonstrate its capacity to influence intracellular signaling networks involved in inflammation and cell fate. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 44 mg/mL (196.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.