CAS No. 118-08-1
Batch:
Purity:99.48
Chemical Structure
Check the
Hydrastine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (3S)-6,7-dimethoxy-3-[(5R)-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3H-2-benzofuran-1-one | |
|---|---|---|
| CAS Number | 118-08-1 | |
| Molecular Formula |
C21H21NO6 |
|
| Molecular Weight (MW) | 383.40 | |
| SMILES | COC1=CC=C2C(OC(=O)C2=C1OC)C3N(C)CCC4=C3C=C5OCOC5=C4 | |
| InChIKey | JZUTXVTYJDCMDU-MOPGFXCFSA-N |
Hydrastine ((-)-β-Hydrastine) is a natural isoquinoline alkaloid present in Hydrastis canadensis that acts as an inhibitor of p21-activated kinase 4 (PAK4). By targeting these signaling networks, hydrastine produces smooth muscle relaxant effects in isolated airway tissue and functions as a competitive antagonist at GABAA receptors, modulating central nervous system excitability and neurotransmitter signaling pathways.[1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
77 mg/mL
(200.83 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.