CAS No. 188844-34-0
Batch:
Purity:98.33
Chemical Structure
Check the
HX531
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 188844-34-0 | |
|---|---|---|
| Molecular Formula |
C29H29N3O4 |
|
| Molecular Weight (MW) | 483.56 |
Biological Activity
HX531 is an orally active retinoid X receptor (RXR) antagonist. It inhibits transactivation mediated by RAR-RXR heterodimers and RXR homodimers, abrogating retinoic acid-induced anti-apoptotic effects. Furthermore, HX531 enhances activation of the p53–p21Cip1 pathway, leading to G0/G1 cell cycle arrest and the suppression of cellular hypertrophy in adipocytes, thereby exhibiting potent anti-obesity, anti-diabetic, and anti-melanoma properties.[1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
10 mg/mL
(20.67 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.