CAS No. 1637443-98-1
Batch:
Purity:99.88
Chemical Structure
Check the
hVEGF-IN-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[2-[4-[4-[2-(diethylamino)ethoxy]anilino]quinazolin-2-yl]phenyl]-3-(4-methylpiperazin-1-yl)propanamide | |
|---|---|---|
| CAS Number | 1637443-98-1 | |
| Molecular Formula |
C34H43N7O2 |
|
| Molecular Weight (MW) | 581.75 | |
| SMILES | CCN(CC)CCOC1=CC=C(NC2=NC(=NC3=C2C=CC=C3)C4=C(NC(=O)CCN5CCN(C)CC5)C=CC=C4)C=C1 | |
| InChIKey | VIBJAHJNWHZSJP-UHFFFAOYSA-N |
hVEGF-IN-1 is a quinazoline derivative that specifically binds to the G-rich sequence in internal ribosome entry site A (IRES-A) with a Kd of. This binding destabilizes the RNA G-quadruplex structure within the 5′-untranslated region of VEGF-A mRNA, downregulating cap-independent translation of VEGF-A. Consequently, decreased VEGF-A expression impairs tumor cell migration and represses tumor growth. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Ethanol | 50 mg/mL |
| DMSO |
25 mg/mL
(42.97 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.