CAS No. 148081-72-5

Batch: Purity:99.95
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HTHQ (1-O-Hexyl-2,3,5-trimethylhydroquinone) Chemical Structure
Chemical Structure
Check the HTHQ (1-O-Hexyl-2,3,5-trimethylhydroquinone) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 148081-72-5
Molecular Formula

C15H24O2
Molecular Weight (MW) 236.35
SMILES CCCCCCOC1=C(C(=C(C(=C1)C)O)C)C

Biological Activity

HTHQ (1-O-Hexyl-2,3,5-trimethylhydroquinone) is a lipid-soluble hydroquinone monoalkylether that acts as a potent antioxidant and anti-lipid-peroxidative agent. It directly scavenges reactive oxygen species (ROS), including peroxyl radicals, converting them into stable free radicals. By suppressing lipid peroxidation and reducing intracellular oxidative stress, HTHQ protects cellular membranes from oxidative degradation and modulates downstream oxidative pathways.

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 47 mg/mL (198.85 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.