CAS No. 1892594-93-2
Batch:
Purity:99.01
Chemical Structure
Check the
HS94
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-methyl-2-[(4-oxo-1-phenyl-5H-pyrazolo[5,4-d]pyrimidin-6-yl)sulfanyl]propanamide | |
|---|---|---|
| CAS Number | 1892594-93-2 | |
| Molecular Formula |
C15H15N5O2S |
|
| Molecular Weight (MW) | 329.38 | |
| InChIKey | HIGNONZTHOPLMQ-UHFFFAOYSA-N |
HS94 is a selective death-associated protein kinase 3 (DAPK3) inhibitor with an inhibition constant (Ki) of, exhibiting over-fold selectivity over Pim kinases. By targeting DAPK3, HS94 inhibits downstream phosphorylation events in vascular smooth muscle, serving as a chemical tool to investigate DAPK3-dependent signaling pathways regulating vascular tone and hypertension. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
17 mg/mL
(51.61 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.