CAS No. 2767422-72-8
| IUPAC Name | 3-N-[6-(piperidin-1-ylmethyl)-1-propylbenzimidazol-2-yl]benzene-1,3-dicarboxamide | |
|---|---|---|
| CAS Number | 2767422-72-8 | |
| Molecular Formula | ||
| Molecular Weight (MW) | 419.5 | |
| SMILES | CCC[N]1C(=NC2=CC=C(CN3CCCCC3)C=C12)NC(=O)C4=CC=CC(=C4)C(N)=O | |
| InChIKey | NPEMHKSMWPZEOV-UHFFFAOYSA-N |
HS-276 is a potent, orally bioavailable, and highly selective transforming growth factor-β-activated kinase 1 (TAK1) inhibitor with a Ki of 2.5 nM. Inhibition of TAK1 disrupts TNF-mediated intracellular signaling and downstream NF-κB activation, thereby reducing proinflammatory cytokine profiles. Consequently, HS-276 suppresses inflammatory responses, leading to significant attenuation of disease severity and arthritic-like symptoms in collagen-induced arthritis mouse models. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
2 mg/mL
(4.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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