CAS No. 1276110-06-5

Batch: Purity:99.08
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HS-173 Chemical Structure
Chemical Structure
Check the HS-173 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name ethyl 6-[5-(benzenesulfonamido)-3-pyridinyl]imidazo[1,2-a]pyridine-3-carboxylate
CAS Number 1276110-06-5
Molecular Formula

C21H18N4O4S
Molecular Weight (MW) 422.46
SMILES CCOC(=O)C1=CN=C2N1C=C(C=C2)C3=CC(=CN=C3)NS(=O)(=O)C4=CC=CC=C4
InChIKey SEKOTFCHZNXZMM-UHFFFAOYSA-N

Biological Activity

HS-173 is a potent small-molecule inhibitor targeting phosphatidylinositol 3-kinase alpha (PI3Kα). By suppressing PI3Kα activity, this compound inhibits the downstream AKT/mTOR signaling cascade, which plays a central role in regulating cell cycle progression, cellular growth, and survival. Blockade of this signaling pathway ultimately leads to decreased cancer cell proliferation, suppression of tumor angiogenesis, and induction of apoptotic cell death in target cells. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 42 mg/mL (99.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Engelman JA. Nat Rev Cancer. 2009;9(8):550-62.

[2] Thorpe LM, et al. Nat Rev Cancer. 2015;15(1):7-24.

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Note: Technical data last updated: Sep 1, 2026.