CAS No. 2158197-70-5
Batch:
Purity:98.11
Chemical Structure
Check the
HS-1371
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 4-(4-methylphenoxy)-7-(1-piperidin-4-ylpyrazol-4-yl)quinoline | |
|---|---|---|
| CAS Number | 2158197-70-5 | |
| Molecular Formula |
C24H24N4O |
|
| Molecular Weight (MW) | 384.47 | |
| SMILES | CC1=CC=C(C=C1)OC2=C3C=CC(=CC3=NC=C2)C4=CN(N=C4)C5CCNCC5 | |
| InChIKey | VPVLPCIBKVWFDT-UHFFFAOYSA-N |
Biological Activity
HS-1371 is an ATP-competitive inhibitor of receptor-interacting protein kinase 3 (RIP3). By occupying the ATP-binding site of RIP3, the compound blocks RIP3 enzymatic activity and inhibits downstream necroptotic signaling pathways. Consequently, HS-1371 suppresses TNF-induced programmed necrosis and protects cells from RIP3-dependent necroptosis, serving as a valuable chemical tool for investigating necroptosis-mediated cellular injury and inflammatory cascades. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
13 mg/mL
(33.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.