CAS No. 2134096-03-8
Batch:
Purity:97.62
Chemical Structure
Check the
HS-10296 hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[5-[[4-(1-cyclopropylindol-3-yl)pyrimidin-2-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide;hydrochloride | |
|---|---|---|
| CAS Number | 2134096-03-8 | |
| Molecular Formula |
C30H35N7O2.ClH |
|
| Molecular Weight (MW) | 562.11 | |
| InChIKey | CUXBWKDZKQGJNN-UHFFFAOYSA-N |
HS-10296 hydrochloride is an irreversible, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that potently targets EGFR-sensitizing mutations, including exon 19 deletions and L858R, alongside the T790M resistance mutation. By blocking EGFR phosphorylation and suppressing downstream RAS/RAF/MEK/ERK and PI3K/AKT/mTOR signaling cascades, it inhibits cell proliferation and induces apoptosis in EGFR-mutant cancer models.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 25 mg/mL |
| DMSO |
13 mg/mL
(23.12 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.