CAS No. 2369583-33-3
Batch:
Purity:97.43
Chemical Structure
Check the
HRX215
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[2,6-difluoro-3-(5-pyridin-4-yl-2H-pyrazolo[3,4-b]pyridine-3-carbonyl)phenyl]propane-1-sulfonamide | |
|---|---|---|
| CAS Number | 2369583-33-3 | |
| Molecular Formula |
C21H17F2N5O3S |
|
| Molecular Weight (MW) | 457.46 | |
| InChIKey | WBNMARNYIFMNEP-UHFFFAOYSA-N |
HRX215 (Darizmetinib) is a first-in-class, selective, orally active mitogen-activated protein kinase kinase 4 (MKK4) inhibitor with an ICof. By suppressing MKK4 within the stress-activated protein kinase pathway, HRX215 redirects signaling through MKKand JNK1 to activate pro-regenerative gene programs. This targeted inhibition promotes hepatocyte proliferation, accelerates liver tissue regeneration, and prevents liver failure in preclinical models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
92 mg/mL
(201.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.