CAS No. 2924841-79-0
Batch:
Purity:95.54
Chemical Structure
Check the
HRS‑5346
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 2924841-79-0 | |
|---|---|---|
| Molecular Formula |
C43H56N4O7 |
|
| Molecular Weight (MW) | 740.93 | |
| SMILES | O=C(O)[C@H]([C@H]1CCNC1)CC2=CC=CC(CN(CC3=CC(C[C@H](C(O)=O)[C@H]4CCNC4)=CC=C3)CCOC5=CC(C[C@H](C(O)=O)[C@H]6CCNC6)=CC=C5)=C2 |
HRS-5346 is an orally bioavailable inhibitor of lipoprotein(a) that targets apolipoprotein(a) and apolipoprotein B protein assembly. By disrupting the assembly of Apo(a) and ApoB, this compound prevents the formation of circulating lipoprotein(a) complexes, leading to suppressed plasma lipoprotein(a) levels and attenuated proatherogenic signaling. Consequently, HRS-5346 serves as a valuable tool for investigating lipid metabolism and cardiovascular disorders.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(134.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | 100 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.