CAS No. 3033864-81-9
Batch:
Purity:98.45
Chemical Structure
Check the
HRS-4642
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-ethyl-6-fluoro-4-[(4R,7S,8S)-14-fluoro-17-[[(2R,8S)-2-fluoro-1,2,3,5,6,7-hexahydropyrrolizin-8-yl]methoxy]-10-oxa-2,12,16,18,20-pentazapentacyclo[9.7.1.14,7.02,8.015,19]icosa-1(18),11,13,15(19),16-pentaen-13-yl]naphthalen-2-ol | |
|---|---|---|
| CAS Number | 3033864-81-9 | |
| Molecular Formula |
C34H35F3N6O3 |
|
| Molecular Weight (MW) | 632.69 | |
| InChIKey | XLWBILUNGOIIFR-OWBPVYLJSA-N |
HRS-4642 is a potent and selective inhibitor of mutant KRAS G12D. Selective inhibition of KRAS G12D suppresses downstream RAS/MAPK and PI3K/AKT signaling pathways, blocking oncogenic signal transduction. Consequently, target inhibition impairs cellular proliferation and demonstrates robust anti-tumor activity against KRAS G12D-mutant cancers in both in vitro and in vivo models. Direct targeting of mutant KRAS provides an effective strategy for driver-mutated malignancies. [1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
190 mg/mL
(300.3 mM)
; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 25 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.