CAS No. 2869954-34-5
Batch:
Purity:99.95
Chemical Structure
Check the
HRO761
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[2-chloro-4-(trifluoromethyl)phenyl]-2-[2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-(5-hydroxy-6-methylpyrimidine-4-carbonyl)piperazin-1-yl]-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4-yl]acetamide | |
|---|---|---|
| CAS Number | 2869954-34-5 | |
| Molecular Formula |
C31H31ClF3N9O5 |
|
| Molecular Weight (MW) | 702.08 | |
| InChIKey | XKYVECRUZPCRQR-UHFFFAOYSA-N |
HRO761 is a potent, selective, allosteric inhibitor of Werner syndrome RecQ helicase (WRN). By binding at the interface of the D1 and D2 helicase domains, HRO761 locks WRN in an inactive conformation and promotes target degradation. This inhibition impairs genomic stability maintenance, triggering DNA damage accumulation and selective tumor cell growth inhibition in microsatellite instability (MSI) cancer cells. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(142.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
33 mg/mL
(47.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(142.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(142.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(142.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- HRO761 Mechanism of Action: WRN Inhibition in MSI-H Cancer Cells Research
- HRO761 Clinical Trials
- HRO761 Solubility in DMSO
- HRO761 Stock Solution
- HRO761 Storage
- HRO761 Stability
- HRO761 Combination Database
- HRO761 Molecular Weight
- HRO761 Chemical Structure (2D and 3D)
- HRO761 MedChemExpress (HY-148699)? Try a better option.
- HRO761 Cayman (41596)? Try a better option.
- HRO761 Sigma (AMBH9A6264D8)? Try a better option.
- HRO761 Abmole (M49839)? Try a better option.
- HRO761 SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.