CAS No. 1325721-55-8
Batch:
Purity:99.04
Chemical Structure
Check the
HPPE
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[2-(2-hydroxyethoxy)ethyl]-1-methyl-2-[[6-(trifluoromethyl)-1,3-benzothiazol-2-yl]amino]benzimidazole-5-carboxamide | |
|---|---|---|
| CAS Number | 1325721-55-8 | |
| Molecular Formula |
C21H20F3N5O3S |
|
| Molecular Weight (MW) | 479.48 | |
| InChIKey | BJSHVWKLYLAKTP-UHFFFAOYSA-N |
HPPE is a specific, non-electrophilic Bach1 inhibitor that derepresses Bach1-mediated transcriptional repression. By modulating Bach1 function, HPPE derepresses antioxidant response element (ARE) gene transcription and enhances cytoprotective pathways, including NRF2-regulated antioxidant signaling. Consequently, this downstream cascade attenuates neuroinflammation, mitigates reactive oxygen species accumulation, and exerts robust neuroprotective effects in preclinical disease models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
96 mg/mL
(200.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.