CAS No. 2244520-98-5

Batch: Purity:99.51
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Homo-PROTAC cereblon degrader 1 Chemical Structure
Chemical Structure
Check the Homo-PROTAC cereblon degrader 1 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-(2,6-dioxopiperidin-3-yl)-4-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethylamino]isoindole-1,3-dione
CAS Number 2244520-98-5
Molecular Formula

C32H32N6O10
Molecular Weight (MW) 660.63
InChIKey OXIPFLHBDVDLDS-UHFFFAOYSA-N

Ordering Information

Biological Activity

Homo-PROTAC cereblon degrader 1 is a homobifunctional proteolysis targeting chimera (PROTAC) that selectively targets and promotes the degradation of cereblon (CRBN). By inducing CRBN dimerization and E3 ubiquitin ligase recruitment, it leads to the targeted self-degradation of CRBN with minimal off-target effects on neosubstrates IKZF1 and IKZF3. This selective target depletion disrupts CRBN-mediated signaling and provides a functional tool for studying ubiquitin-proteasome pathway mechanisms. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (151.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.