CAS No. 2519537-70-1
Batch:
Purity:99.19
Chemical Structure
Check the
HOIPIN-8
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | sodium 2-[(E)-3-[2,6-difluoro-4-(1H-pyrazol-4-yl)phenyl]-3-oxoprop-1-enyl]-4-(1-methylpyrazol-4-yl)benzoate | |
|---|---|---|
| CAS Number | 2519537-70-1 | |
| Molecular Formula |
C23H15F2N4NaO3 |
|
| Molecular Weight (MW) | 456.38 | |
| InChIKey | DLJPWYFLGYVMKV-WGCWOXMQSA-M |
Biological Activity
HOIPIN-8 is a potent inhibitor of the linear ubiquitin chain assembly complex (LUBAC, IC50 = 11 nM) that suppresses NF-κB signaling [1]. By blocking LUBAC-mediated linear ubiquitination, it downregulates TNF-α-stimulated canonical NF-κB activation and pathogen-induced immune pathways [1, 2]. Consequently, HOIPIN-8 impairs downstream inflammatory cytokine expression, alters cell death responses, and serves as a valuable tool for investigating LUBAC-dependent physiological functions in cellular immunity.[1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
30 mg/mL
(65.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.