CAS No. 926908-04-5
Chemical Structure
Check the
HNHA
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-hydroxy-7-naphthalen-2-ylsulfanylheptanamide | |
|---|---|---|
| CAS Number | 926908-04-5 | |
| Molecular Formula |
C17H21NO2S |
|
| Molecular Weight (MW) | 303.42 | |
| InChIKey | KPNNXHVGOKRBEF-UHFFFAOYSA-N |
Biological Activity
HNHA is a cell-permeable inhibitor of histone deacetylase (HDAC) activity, serving as a key modulator of gene expression and chromatin remodeling. By blocking HDAC-mediated histone deacetylation, it increases histone acetylation levels and alters transcriptional regulation. This inhibition suppresses cancer cell proliferation and triggers downstream phenotypes, including cell cycle arrest and apoptosis, ultimately demonstrating anti-tumor activity both in vitro and in vivo. [1]
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Note: Technical data last updated: Sep 1, 2026.