CAS No. 173529-10-7
Batch:
Purity:99.17
Chemical Structure
Check the
HMN-176
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[6-[2-(1-hydroxy-4-pyridinylidene)ethylidene]cyclohexa-2,4-dien-1-ylidene]-4-methoxybenzenesulfonamide | |
|---|---|---|
| CAS Number | 173529-10-7 | |
| Molecular Formula |
C20H18N2O4S |
|
| Molecular Weight (MW) | 382.43 | |
| SMILES | COC1=CC=C(C=C1)S(=O)(=O)N=C2C=CC=CC2=CC=C3C=CN(C=C3)O | |
| InChIKey | MYEJOKLXXLVMPR-UHFFFAOYSA-N |
HMN-176 is an active metabolite of HMN-214 that acts as a potent antitumor agent targeting polo-like kinase 1 (PLK1). It inhibits PLK1 functionality by disrupting its normal spatial distribution at centrosomes and along cytoskeletal structures. This interference impairs mitotic spindle dynamics, leading to cell cycle arrest at the G2/M phase and subsequent induction of apoptosis in cancer cells, thereby suppressing tumor proliferation. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
76 mg/mL
(198.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.