CAS No. 2569527-64-4
Batch:
Purity:99.92
Chemical Structure
Check the
HM43239
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-chloro-N-[3-cyclopropyl-5-[[(3S,5R)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]-4-(6-methyl-1H-indol-3-yl)pyrimidin-2-amine | |
|---|---|---|
| CAS Number | 2569527-64-4 | |
| Molecular Formula |
C29H33ClN6 |
|
| Molecular Weight (MW) | 501.07 | |
| SMILES | CC1CN(CC(C)N1)CC2=CC(=CC(=C2)NC3=NC=C(Cl)C(=N3)C4=C[NH]C5=C4C=CC(=C5)C)C6CC6 | |
| InChIKey | FZLSDZZNPXXBBB-KDURUIRLSA-N |
HM43239 is a potent small-molecule inhibitor of FMS-like tyrosine kinase 3 (FLT3), targeting wild-type FLT3 as well as internal tandem duplication (ITD) and tyrosine kinase domain (TKD) mutations. By suppressing FLT3 kinase signaling, it inhibits downstream STAT5, AKT, and ERK pathway activation. This targeted inhibition impairs leukemic cell proliferation and induces apoptosis in acute myeloid leukemia models driven by wild-type or mutant FLT3 signaling.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
50 mg/mL
(99.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 12.5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.