CAS No. 854847-61-3
Batch:
Purity:99.83
Chemical Structure
Check the
HLY78
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 854847-61-3 | |
|---|---|---|
| Molecular Formula |
C17H17NO2 |
|
| Molecular Weight (MW) | 267.32 | |
| SMILES | CCC1=C2N(C)CC3=CC4=C(OCO4)C=C3C2=CC=C1 |
HLY78 is a small-molecule activator of the Wnt/β-catenin signaling pathway that targets the DIX domain of Axin. By promoting Axin dimerization and enhancing LRP6 phosphorylation, HLY78 activates downstream Wnt-dependent gene expression and cellular responses. Consequently, activation of this signaling cascade enhances cell survival and inhibits apoptosis induced by carbon ion radiation in both tumor cells and embryonic cells.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
53 mg/mL
(198.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 26 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.