CAS No. 353519-63-8
Batch:
Purity:99.57
Chemical Structure
Check the
HLM006474
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 7-[(4-ethoxy-3-methylphenyl)-(pyridin-2-ylamino)methyl]-2-methylquinolin-8-ol | |
|---|---|---|
| CAS Number | 353519-63-8 | |
| Molecular Formula |
C25H25N3O2 |
|
| Molecular Weight (MW) | 399.48 | |
| SMILES | CCOC1=C(C=C(C=C1)C(C2=C(C3=C(C=CC(=N3)C)C=C2)O)NC4=CC=CC=N4)C | |
| InChIKey | CYNZBLNMIJNBSF-UHFFFAOYSA-N |
HLM006474 is a pan-E2F inhibitor that inhibits E2F4 DNA binding with an IC50 ofin A375 cells. By disrupting the CDK/Rb/E2F signaling pathway, HLM006474 downregulates E2F transcriptional activity, suppresses cancer cell proliferation, and promotes apoptosis. In preclinical models, including lung cancer, it effectively inhibits tumor cell growth and invasive phenotypes. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
10 mg/mL
(25.03 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | ˂1 mg/mL |
| Ethanol | ˂1 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.