CAS No. 1447-88-7
Batch:
Purity:99.79
Chemical Structure
Check the
Hispidulin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxychromen-4-one | |
|---|---|---|
| CAS Number | 1447-88-7 | |
| Molecular Formula |
C16H12O6 |
|
| Molecular Weight (MW) | 300.26 | |
| SMILES | COC1=C(O)C=C2OC(=CC(=O)C2=C1O)C3=CC=C(O)C=C3 | |
| InChIKey | IHFBPDAQLQOCBX-UHFFFAOYSA-N |
Hispidulin is a naturally occurring flavone that acts as an inhibitor of Pim-1 kinase. It exerts potent antineoplastic activity by suppressing cell proliferation and inducing apoptosis through mitochondrial dysfunction and inhibition of the PI3K/AKT signaling pathway in HepG2 cancer cells. Furthermore, hispidulin exhibits anti-osteoporotic effects and attenuates osteoclast-mediated bone resorption via activation of the AMPK signaling pathway. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
60 mg/mL
(199.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(333.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| DMSO |
60 mg/mL
(199.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.