CAS No. 555-55-5
Batch:
Purity:97.76
Chemical Structure
Check the
Hispidin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 6-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-4-hydroxypyran-2-one | |
|---|---|---|
| CAS Number | 555-55-5 | |
| Molecular Formula |
C₁₃H₁₀O₅ |
|
| Molecular Weight (MW) | 246.22 | |
| InChIKey | SGJNQVTUYXCBKH-HNQUOIGGSA-N |
Biological Activity
Hispidin is a phenolic compound that acts as an inhibitor of protein kinase Cβ (PKCβ) with an IC50 of 2 μM, beta-secretase (BACE1) with an IC50 of, and prolyl endopeptidase (PE) with an IC50 of. Inhibition of PKC signaling and secretase pathways disrupts cellular growth and amyloidogenic processing. Consequently, hispidin demonstrates anti-cancer cytotoxicity in human cancer cells and anti-dementia potential.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
49 mg/mL
(199.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.