CAS No. 1315329-43-1
Batch:
Purity:99.02
Chemical Structure
Check the
HG6-64-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[(E)-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-5-yl)ethenyl]-4-methylbenzamide | |
|---|---|---|
| CAS Number | 1315329-43-1 | |
| Molecular Formula |
C32H34F3N5O2 |
|
| Molecular Weight (MW) | 577.64 | |
| InChIKey | UMBFDGUGXMOMHX-BQYQJAHWSA-N |
HG-4-1 is a highly potent and selective inhibitor of B-Raf in B-Raf VE-transformed Ba/Fcells). By effectively suppressing RAF/MAPK kinase pathway signaling, HG-4-1 impairs downstream oncogenic cascade activation. This disruption leads to markedly suppressed cancer cell proliferation, attenuated survival signaling, and the robust induction of cell cycle arrest and apoptosis across transformed cellular models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(173.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.