CAS No. 928712-10-1
| IUPAC Name | 2-chloro-N-[2-(4-methoxyphenyl)benzotriazol-5-yl]acetamide | |
|---|---|---|
| CAS Number | 928712-10-1 | |
| Molecular Formula |
C15H13ClN4O2 |
|
| Molecular Weight (MW) | 316.74 | |
| SMILES | COC1=CC=C(C=C1)[N]2N=C3C=CC(=CC3=N2)NC(=O)CCl | |
| InChIKey | YKONCCSKKBLMDS-UHFFFAOYSA-N |
HG106 is a potent small-molecule inhibitor of the solute carrier family 7 member 11 (SLC7A11) cystine/glutamate antiporter. Pharmacological inhibition of SLC7A11 by HG106 blocks cellular cystine uptake and depletes intracellular glutathione levels. This disruption triggers enhanced reactive oxygen species (ROS) generation and endoplasmic reticulum (ER) stress, culminating in selective cell apoptosis and growth arrest in KRAS-mutant lung adenocarcinoma. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
26 mg/mL
(82.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
21 mg/mL
(66.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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