CAS No. 1456858-58-4
Batch:
Purity:99.81
Chemical Structure
Check the
HG-9-91-01
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-(2,4-dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-[6-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]urea | |
|---|---|---|
| CAS Number | 1456858-58-4 | |
| Molecular Formula |
C32H37N7O3 |
|
| Molecular Weight (MW) | 567.68 | |
| SMILES | CC1=C(C(=CC=C1)C)NC(=O)N(C2=C(C=C(C=C2)OC)OC)C3=NC=NC(=C3)NC4=CC=C(C=C4)N5CCN(CC5)C | |
| InChIKey | UYUHRKLITDJEHB-UHFFFAOYSA-N |
HG-9-91-01 is a potent and selective salt-inducible kinase inhibitor targeting SIK1 (IC50 0.92 nM), SIK2 (IC50 6.6 nM), and SIK3 (IC50 9.6 nM). By suppressing SIK activity, it promotes the dephosphorylation and nuclear translocation of CRTC transcription coactivators and HDAC4/5, thereby enhancing anti-inflammatory cytokine expression such as IL-10 while suppressing pro-inflammatory factors in immune cells.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(176.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.