CAS No. 140898-91-5

Batch: Purity:98.81
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Hexaminolevulinate hydrochloride Chemical Structure
Chemical Structure
Check the Hexaminolevulinate hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 140898-91-5
Molecular Formula

C11H21NO3.ClH
Molecular Weight (MW) 251.75
SMILES Cl.CCCCCCOC(=O)CCC(=O)CN

Ordering Information

Biological Activity

Hexaminolevulinate hydrochloride is a lipophilic hexyl ester prodrug of 5-aminolevulinic acid that serves as a precursor for the photosensitizer protoporphyrin IX. Upon cellular entry, it increases intracellular protoporphyrin IX accumulation and, following photoactivation, triggers cytochrome c release, caspase-3 and caspase-9 activation, and apoptosis via both caspase-dependent and apoptosis-inducing factor-mediated caspase-independent pathways. Photoactivated hexaminolevulinate also reduces MDR1 P-glycoprotein expression to reverse multidrug resistance in human cancer cells. [1][2]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 50 mg/mL (198.6 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 50 mg/mL
Ethanol 50 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.