CAS No. 527-95-7
Batch:
Purity:99.85
Chemical Structure
Check the
Herbacetin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 3,5,7,8-tetrahydroxy-2-(4-hydroxyphenyl)chromen-4-one | |
|---|---|---|
| CAS Number | 527-95-7 | |
| Molecular Formula |
C15H10O7 |
|
| Molecular Weight (MW) | 302.24 | |
| InChIKey | ZDOTZEDNGNPOEW-UHFFFAOYSA-N |
Biological Activity
Herbacetin is a natural flavonoid that acts as an allosteric inhibitor of ornithine decarboxylase (ODC) and a kinase inhibitor of serum/glucocorticoid-regulated kinase 1 (SGK1) with an ICof. Inhibition of ODC disrupts polyamine biosynthesis to suppress colon cancer cell proliferation, whereas SGK1 blockade modulates downstream FoxO1 signaling to attenuate cardiomyocyte hypertrophy and reduce reactive oxygen species production. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
60 mg/mL
(198.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| DMSO |
60 mg/mL
(198.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.