CAS No. 475-25-2
Batch:
Purity:99
Chemical Structure
Check the
Hematein
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4,6a,9,10-tetrahydroxy-6,7-dihydroindeno[2,1-c]chromen-3-one | |
|---|---|---|
| CAS Number | 475-25-2 | |
| Molecular Formula |
C16H12O6 |
|
| Molecular Weight (MW) | 300.26 | |
| SMILES | OC1=CC2=C(C=C1O)C3=C4C=CC(=O)C(=C4OCC3(O)C2)O | |
| InChIKey | HNNSUZPWERIYIL-UHFFFAOYSA-N |
Hematein is a selective casein kinase II (CK2) inhibitor (IC50 = 0.55 μM in the presence of 10 μM ATP) that acts in an ATP non-competitive manner. By inhibiting CK2 activity, hematein downregulates downstream Akt pathway signaling through reduced Akt phosphorylation. Consequently, suppression of this survival pathway inhibits cell proliferation and suppresses tumor growth while inducing apoptosis.[1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
60 mg/mL
(199.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.