CAS No. 19210-12-9

Batch: Purity:99.89
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Harpagoside Chemical Structure
Chemical Structure
Check the Harpagoside product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 19210-12-9
Molecular Formula

C24H30O11
Molecular Weight (MW) 494.49
SMILES CC1(CC(C2(C1C(OC=C2)OC3C(C(C(C(O3)CO)O)O)O)O)O)OC(=O)C=CC4=CC=CC=C4

Ordering Information

Biological Activity

Harpagoside is a natural iridoid glycoside isolated from Harpagophytum procumbens with anti-inflammatory and analgesic activities. It suppresses lipopolysaccharide-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) through inhibition of the NF-κB signaling pathway. Attenuation of NF-κB activation reduces the production of pro-inflammatory mediators, mediating its protective role in inflammatory and rheumatic responses.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 99 mg/mL (200.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 99 mg/mL
Ethanol 99 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.