CAS No. 442-51-3

Batch: Purity:99.97
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Harmine Chemical Structure
Chemical Structure
Check the Harmine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 442-51-3
Molecular Formula

C13H12N2O
Molecular Weight (MW) 212.25
SMILES CC1=NC=CC2=C1NC3=C2C=CC(=C3)OC

Ordering Information

Biological Activity

Harmine is a cell-permeable beta-carboline alkaloid that acts as a potent, ATP-competitive inhibitor of dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) and cdc-like kinases (CLKs). It also inhibits monoamine oxidases and interacts with 5-HT2A serotonin receptors. By suppressing DYRK1A activity, harmine modulates downstream Wnt signaling pathways and regulates PPARγ expression, influencing cellular proliferation, neurogenesis, and metabolic processes.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 42 mg/mL (197.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.