CAS No. 74050-97-8

Batch: Purity:99.82
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Haloperidol Decanoate Chemical Structure
Chemical Structure
Check the Haloperidol Decanoate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 74050-97-8
Molecular Formula

C31H41ClFNO3
Molecular Weight (MW) 530.11
SMILES CCCCCCCCCC(=O)OC1(CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1)C3=CC=C(Cl)C=C3

Ordering Information

Biological Activity

Haloperidol decanoate is a long-acting depot prodrug of haloperidol that acts primarily as a potent dopamine D2 receptor antagonist. Upon administration, it undergoes enzymatic hydrolysis to release haloperidol, which selectively blocks postsynaptic dopamine D2 receptors in the central nervous system. This inhibition modulates dopaminergic signaling pathways, downstream neurotransmitter release, and behavioral responses, making it a valuable tool for studying dopaminergic pathway dysregulation in psychiatric disorder models. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (188.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.