CAS No. 55837-20-2
| IUPAC Name | 7-bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one | |
|---|---|---|
| CAS Number | 55837-20-2 | |
| Molecular Formula |
C16H17BrClN3O3 |
|
| Molecular Weight (MW) | 414.68 | |
| SMILES | C1CC(C(NC1)CC(=O)CN2C=NC3=CC(=C(C=C3C2=O)Cl)Br)O | |
| InChIKey | LVASCWIMLIKXLA-CABCVRRESA-N |
Halofuginone is a competitive inhibitor of prolyl-tRNA synthetase with a Ki of. By inhibiting prolyl-tRNA synthetase, it blocks proline incorporation during protein synthesis and downregulates Smad3 phosphorylation to inhibit TGF-β signaling. Consequently, these cellular effects attenuate collagen synthesis, reduce fibrotic responses, and suppress Th17 cell differentiation through activation of the amino acid starvation response in mammalian systems. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
8 mg/mL
(19.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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