CAS No. 64924-67-0
Batch:
Purity:99.68
Check the
Halofuginone hydrobromide
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 64924-67-0 | |
|---|---|---|
| Molecular Formula |
C16H18Br2ClN3O3 |
|
| Molecular Weight (MW) | 495.59 |
Halofuginone hydrobromide, a febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM [1]. Specific target inhibition suppresses aminoacyl-tRNA charging and attenuates downstream TGF-β signaling pathways [1, 2]. Consequently, halofuginone specifically inhibits type-I collagen synthesis, reduces subchondral bone deterioration, and limits aberrant angiogenesis, effectively mitigating disease progression in osteoarthritis and tissue fibrosis models [1, 2].[1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
16 mg/mL
(32.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 2 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.