CAS No. 3093-35-4

Batch: Purity:99.93
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Halcinonide Chemical Structure
Chemical Structure
Check the Halcinonide product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 3093-35-4
Molecular Formula

C24H32ClFO5
Molecular Weight (MW) 454.96
SMILES CC1(OC2CC3C4CCC5=CC(=O)CCC5(C4(C(CC3(C2(O1)C(=O)CCl)C)O)F)C)C

Ordering Information

Biological Activity

Halcinonide (SQ-18566) is a high-potency synthetic corticosteroid that functions as a glucocorticoid receptor agonist. Upon activation, the glucocorticoid receptor translocates to the nucleus to regulate gene expression and suppress pro-inflammatory signaling mediated by NF-kB. This transcriptional regulation inhibits the production of key inflammatory cytokines, leading to downstream suppression of cellular immune responses and inflammatory phenotypes.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 91 mg/mL (200.01 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 5 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.