CAS No. 2052128-15-9
Batch:
Purity:98.06
Chemical Structure
Check the
H3B-5942
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 2052128-15-9 | |
|---|---|---|
| Molecular Formula |
C31H34N4O2 |
|
| Molecular Weight (MW) | 494.63 | |
| SMILES | CCC(=C(C1=CC=C(C=C1)OCCNCC=CC(=O)N(C)C)C2=CC3=C(C=C2)NN=C3)C4=CC=CC=C4 |
H3B-5942 is a selective and irreversible covalent antagonist of estrogen receptor alpha (ERα) that inactivates both wild-type ERα and mutant ERα forms. Covalent engagement of ERα by H3B-5942 disrupts estrogen receptor-mediated transcriptional signaling pathways, thereby suppressing downstream target gene expression and effectively inhibiting cellular proliferation in estrogen receptor-positive breast cancer cell models. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
99 mg/mL
(200.14 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 13 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.