CAS No. 70-78-0
Batch:
Purity:99.79
Chemical Structure
Check the
H-Tyr(3-I)-OH
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid | |
|---|---|---|
| CAS Number | 70-78-0 | |
| Molecular Formula |
C9H10INO3 |
|
| Molecular Weight (MW) | 307.09 | |
| SMILES | C1=CC(=C(C=C1CC(C(=O)O)N)I)O | |
| InChIKey | UQTZMGFTRHFAAM-ZETCQYMHSA-N |
H-Tyr(3-I)-OH (3-Iodo-L-tyrosine) is a synthetic amino acid derivative and competitive inhibitor of tyrosine hydroxylase. By specifically targeting tyrosine hydroxylase, it suppresses the initial, rate-limiting conversion of L-tyrosine to L-DOPA within the catecholamine pathway. Consequently, this blockade disrupts downstream noradrenergic biosynthesis, leading to reduced endogenous norepinephrine production and altered neurotransmitter signaling in neuronal models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 5 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.