CAS No. 704-15-4

Batch: Purity:99.95
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H-Gly-Pro-OH Chemical Structure
Chemical Structure
Check the H-Gly-Pro-OH product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2S)-1-(2-aminoacetyl)pyrrolidine-2-carboxylic acid
CAS Number 704-15-4
Molecular Formula

C7H12N2O3
Molecular Weight (MW) 172.18
SMILES C1CC(N(C1)C(=O)CN)C(=O)O
InChIKey KZNQNBZMBZJQJO-YFKPBYRVSA-N

Biological Activity

H-Gly-Pro-OH (Glycyl-L-proline) is a naturally occurring dipeptide and a substrate involved in collagen metabolism. It undergoes cleavage by prolidase (peptidase D) to liberate free proline, which is subsequently reutilized for protein synthesis, collagen resynthesis, and cellular matrix remodeling. Additionally, Gly-Pro serves as an endogenous transport substrate for proton-coupled oligopeptide transporters like PEPT1, contributing to intestinal peptide absorption and cellular amino acid homeostasis. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 34 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Fei YJ, et al. Nature. 1994;368(6471):563-6.

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Note: Technical data last updated: Sep 1, 2026.