CAS No. 106740-09-4
| IUPAC Name | (4-methoxyphenyl)-morpholin-4-yl-sulfanyl-sulfanylidene-λ5-phosphane;morpholine | |
|---|---|---|
| CAS Number | 106740-09-4 | |
| Molecular Formula |
C11H16NO2PS2.C4H9NO |
|
| Molecular Weight (MW) | 376.47 | |
| SMILES | COC1=CC=C(C=C1)[P](S)(=S)N2CCOCC2.C3COCCN3 | |
| InChIKey | YZMHNNLDUWRZFW-UHFFFAOYSA-N |
GYY4137 is a slow-releasing, water-soluble hydrogen sulfide (H2S) donor that exhibits potent vasodilator, antihypertensive, and anti-inflammatory activities. Release of H2S modulates vascular tone, causing vasodilation and reduction of blood pressure. In addition, GYY4137 suppresses pro-inflammatory cytokine production and exhibits anti-cancer activity against hepatocellular carcinoma by inhibiting STAT3 signaling, leading to apoptosis and inhibition of cell proliferation. [1][2]
| Solvent | Solubility & Note |
|---|---|
| DMSO |
75 mg/mL
(199.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 25 mg/mL |
| Ethanol | Insoluble |
| DMSO |
75 mg/mL
(199.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 25 mg/mL |
| Ethanol | Insoluble |
| DMSO |
75 mg/mL
(199.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 5 mg/mL |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.