CAS No. 579515-63-2
Batch:
Purity:99.00
Chemical Structure
Check the
GW806742X
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 1-[4-[methyl-[2-(3-sulfamoylanilino)pyrimidin-4-yl]amino]phenyl]-3-[4-(trifluoromethoxy)phenyl]urea | |
|---|---|---|
| CAS Number | 579515-63-2 | |
| Molecular Formula |
C25H22F3N7O4S |
|
| Molecular Weight (MW) | 573.55 | |
| InChIKey | SNRUTMWCDZHKKM-UHFFFAOYSA-N |
Biological Activity
GWX is a small-molecule inhibitor of mixed lineage kinase domain-like protein (MLKL) that binds to the MLKL pseudokinase domain. By targeting this domain, GWX retards MLKL oligomerization and plasma membrane translocation within the necroptosis cell death pathway. Consequently, inhibition of this key effector complex blocks plasma membrane disruption and suppresses necroptotic cell death downstream of inflammatory signaling. [1]
How to Prepare Stock Solution?
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Concentration
Volume
Mass
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Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(174.35 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.