CAS No. 452342-67-5

Batch: Purity:99.99
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GW788388 Chemical Structure
Chemical Structure
Check the GW788388 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-(oxan-4-yl)-4-[4-(5-pyridin-2-yl-1H-pyrazol-4-yl)-2-pyridinyl]benzamide
CAS Number 452342-67-5
Molecular Formula

C25H23N5O2
Molecular Weight (MW) 425.48
SMILES C1COCCC1NC(=O)C2=CC=C(C=C2)C3=NC=CC(=C3)C4=C(NN=C4)C5=CC=CC=N5
InChIKey SAGZIBJAQGBRQA-UHFFFAOYSA-N

Biological Activity

GW788388 is a potent and selective inhibitor of ALK5 binding and cellular TGF-β signaling. It blocks TGF-β-induced Smad activation and downstream gene expression, thereby suppressing epithelial-mesenchymal transition and fibrogenesis. In vivo, oral administration of GW788388 reduces renal fibrosis and downregulates extracellular matrix gene expression in diabetic nephropathy models. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 33 mg/mL (77.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Gellibert F, et al. J Med Chem. 2006;49(7):2210-21.

[2] Petersen M, et al. Kidney Int. 2008;73(6):705-15.

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Note: Technical data last updated: Sep 1, 2026.