GW4869 is a potent, cell-permeable neutral sphingomyelinase (nSMase) inhibitor. It affects exosome-mediated intercellular signaling by blocking nSMase-dependent exosome biogenesis and release, effectively inhibiting tumor progression, metastasis, fibrosis, and inflammation.
GW4869: Mechanism of Action
GW4869 MOA：Targeting nSMase2/Ceramide Pathway for Oncology and Tumor Microenvironment